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Postdoc position in pediatric neurooncology research (m/f/d)

JOB OVERVIEW

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immediately

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Full-time

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40 hours per week

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Jena

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Compensation based on TV-L E13

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Limited*

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Clinic for Pediatric and Adolescent Medicine

We are seeking a talented and driven Postdoctoral Researcher to investigate the biological mechanisms driving pediatric low-grade glioma (pLGG) regrowth following MAPK inhibitor (MAPKi) withdrawal. This project will explore how changes in MAPK pathway activity and microglia recruitment contribute to tumor recurrence, using a combination of molecular biology, cell culture, and microenvironment-focused assays. The findings aim to inform improved treatment strategies and prevent relapse in young patients.

Primary Duties & Responsibilities:

• develop and utilize in vitro and ex vivo models to study pLGG regrowth after MAPKi withdrawal. Assess MAPK pathway reactivation and downstream effects on tumor cell biology
• investigate microglia recruitment and its contribution to tumor recurrence using co-culture systems and functional assays
• integrate experimental results with bioinformatics workflows for comprehensive analysis
• publish in high-impact international journals and present at major scientific conferences
• supervise and mentor PhD, MD, MSc, and BSc students within the project

Required Skills & Qualifications:

• PhD in molecular biology, neurobiology, immunology, cancer biology, or related field
• expertise in molecular and cellular biology methods (e.g., real-time PCR, Western blotting, immunostaining, microscopy)
• experience in tumor–microenvironment studies, particularly microglia or immune cell biology, is desirable
• familiarity with MAPK signaling or targeted therapy research is a plus
• skills in bioinformatics (R, Python) are advantageous
• experience with BSL-2 laboratory work preferred
• experience with the scientific publication process necessary
• excellent English communication skills, written and spoken
• highly motivated, independent, and team-oriented

We offer you even more:

• a stimulating research environment with a strong focus on translational pediatric neuro-oncology
• the opportunity to explore tumor–microenvironment interactions in clinically relevant models
• access to advanced cell culture systems, imaging platforms
• support for career development, including teaching and habilitation opportunities
• offer networking opportunities in national and international pediatric brain tumor research networks (e.g. Everest, Itcc, SIOPE BTG, PLGA coalition)
• Classification is based on TV-L in pay grade E13 if the personal and collective agreement requirements are met.

Reference number: 170/2026

* Limited to 24 months, with option to extend

Regardless of origin, age, gender or disability – you are welcome here at Jena University Hospital.

Benefits:

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secure employment / job

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free continuing education

info including time off

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outlined company pension

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30 vacation days

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outlined employee discounts

info Exclusive employee discounts on well-known brands

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health services

info free prevention courses, consultation of health issues, stress managementps, psychological counselling of employees

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family-friendly measure

info flexible working time models, childcare, …

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Company-sponsored daycare

info from 06:00 – 20:00

restaurant

cafeteria

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assistance in apartment

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company events

Contact:

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Dr. Sigaud Romain

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03641 9-380843

Apply now!

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